I have been working on bioinformatics since my graduate years. In recent years, my work has been mainly on regulatory mechanisms. I try to integrate computing techniques, statistical methods, and data from high-throughput biological experiments. Since the transcription of genes is mainly controlled by the interaction between transcription factors (TFs) and their binding sites (TFBSs), I am particularly interested in inferring the functions of TFs and their recognized TFBSs. I use mainly the baker’s yeast, Saccharomyces cerevisiae, as the model organism.