HK Tsai Lab of Bioinformatics

Institute of Information Science, Academia Sinica


Chinese New Year End Party

We take a one-day trip to 象山, Taipei, and enjoy a pleasant lunch at Nola Kitchen. At the end of the Chinese New Year, we thank all of

BITS Christmas Party

The season of festivities has come and we wish that all of us spend the best time with our family and friends. With Christmas, the new year is also around the corner and our wish for the upcoming year is that we can continue to grow in the same way and at the same pace.

Welcome Our New Research Assistants

Under COVID-19 pandemic, we still have three research assistants joining our laboratory! Welcome Zong-Yan Liu (Thomas), Kai-Li Chang, Ru-Yin Jian! Let’s start dreaming big and making our dreams come true this year!



A bioinformatics-based exploration on the promoter occupancy and alternative splicing in the human genome


Reveal the function of lncRNA on the transcriptional regulation and epigenetic regulation

Lab Members

Principal Investigator


Huai-Kuang Tsai

Research Fellow/Professor

Evolutionary Algorithm, Bioinformatics, Regulatory Mechanism, Metagenomics, Computational Biology



Wong Jin Yung

Postdoctoral Researcher

Evolution, Genomics, Machine Learning, Biomechanics


Kai-Li Chang

Research Assistant

Bioinformatics, Genomics, Cancer biology, Epigenomics, Machine Learning


Ru-Yin Jian

Research Assistant

Machine Learning, Bioinformatics, Cancer


Zong-Yan Liu (Thomas)

Research Assistant

Bioinformatics, Genomics, Gene Regulation, Machine Learning


Jia-Hong Chen


Transformer, Deep Learning, eccDNA

Grad Students


Yu-Hsin Chen

Doctoral Student

Bioinformatics, Proteomics


Visiting Scholars


Jia-Hsin Huang

Assistant Professor

Insect Physiology, Bioinformatics, Genomics


Recent Publications

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Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus.

The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act …

NK cell receptor and ligand composition influences the clearance of SARS-CoV-2

To explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry–based proteomics platform to …

Connecting MHC-I-binding motifs with HLA alleles via deep learning.

The selection of peptides presented by MHC molecules is crucial for antigen discovery. Previously, several predictors have shown …