A delightful lunch and a warm welcome to Serina! Group photo in front of Fulong Train Station — we’re about to start our bike ride! Another shot at the entrance of the Old Caoling Tunnel — little did we know we would end up completing the entire cycling route!

Group photo in front of the restaurant with friends from other labs after the conference. Another group shot taken inside the restaurant. Late-night chats at the lodging — this conference trip will be a lifelong memory.

We gathered to celebrate Dr.Tsai’s birthday — a joyful moment for the whole lab. May this year bring even more success, health, and happiness. Happy birthday!

Enhanced phenotypic diversity increases a population’s likelihood of surviving catastrophic conditions. Hsp90, an essential molecular chaperone and a central network hub in eukaryotes, has been observed to suppress or enhance the effects of genetic variation on phenotypic diversity in response to environmental cues. Because many Hsp90-interacting genes are involved in signaling transduction pathways and transcriptional regulation, we tested how common Hsp90-dependent differential gene expression is in natural populations. Many genes exhibited Hsp90-dependent strain-specific differential expression in five diverse yeast strains. We further identified transcription factors (TFs) potentially contributing to variable expression. We found that on Hsp90 inhibition or environmental stress, activities or abundances of Hsp90-dependent TFs varied among strains, resulting in differential strain-specific expression of their target genes, which consequently led to phenotypic diversity. We provide evidence that individual strains can readily display specific Hsp90-dependent gene expression, suggesting that the evolutionary impacts of Hsp90 are widespread in nature.

Background: Ubiquitous presence of short extrachromosomal circular DNAs (eccDNAs) in eukaryotic cells has perplexed generations of …

With the proliferation of genomic sequence data for biomedical research, the exploration of human genetic information by domain experts …