Bio-IT-Station


HK Tsai Lab of Bioinformatics

Institute of Information Science, Academia Sinica

News

Birthday Party

This week marks Dr. Tsai’s birthday. Despite the fact that we are suffering from the pandemic, we are thrilled to be able to celebrate with our collaborator, Dr. Leu, and his lab members.

Chinese New Year End Party

We take a one-day trip to 象山, Taipei, and enjoy a pleasant lunch at Nola Kitchen. At the end of the Chinese New Year, we thank all of

BITS Christmas Party

The season of festivities has come and we wish that all of us spend the best time with our family and friends. With Christmas, the new year is also around the corner and our wish for the upcoming year is that we can continue to grow in the same way and at the same pace.

Projects

TFAS

A bioinformatics-based exploration on the promoter occupancy and alternative splicing in the human genome

LncRNA

Reveal the function of lncRNA on the transcriptional regulation and epigenetic regulation

Lab Members

Principal Investigator

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Huai-Kuang Tsai

Research Fellow/Professor

Evolutionary Algorithm, Bioinformatics, Regulatory Mechanism, Metagenomics, Computational Biology

Researchers

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Wong Jin Yung

Postdoctoral Researcher

Evolution, Genomics, Machine Learning, Biomechanics

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Ru-Yin Jian

Research Assistant

Machine Learning, Bioinformatics, Cancer

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Bing-Shiun Tsai

Research Assistant

Machine Learning, Bioinformatics

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Kai-Ze Zhu

Research Assistant

Statistical Computation, Machine Learning, Variables Selection in High Dimensional Data, Genomic

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Shu-Qi Yu

Student and former Researcher Assistant

Bioinformatics, Network, Graph Theory, Algorithm

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Chia-Hsuan Chou

Research Assistant

Bioinformatics, Genomics, Epigenomics, Computational Biology

Grad Students

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Yu-Hsin Chen

Doctoral Student

Bioinformatics, Proteomics

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Shang-Kok NG

Doctoral Student

Bioinformatics, Cancer

Administration

Visiting Scholars

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Jia-Hsin Huang

Assistant Professor

Insect Physiology, Bioinformatics, Genomics

Alumni

Recent Publications

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Differential Hsp90-dependent gene expression is strain-specific and common among yeast strains

Enhanced phenotypic diversity increases a population’s likelihood of surviving catastrophic conditions. Hsp90, an essential molecular chaperone and a central network hub in eukaryotes, has been observed to suppress or enhance the effects of genetic variation on phenotypic diversity in response to environmental cues. Because many Hsp90-interacting genes are involved in signaling transduction pathways and transcriptional regulation, we tested how common Hsp90-dependent differential gene expression is in natural populations. Many genes exhibited Hsp90-dependent strain-specific differential expression in five diverse yeast strains. We further identified transcription factors (TFs) potentially contributing to variable expression. We found that on Hsp90 inhibition or environmental stress, activities or abundances of Hsp90-dependent TFs varied among strains, resulting in differential strain-specific expression of their target genes, which consequently led to phenotypic diversity. We provide evidence that individual strains can readily display specific Hsp90-dependent gene expression, suggesting that the evolutionary impacts of Hsp90 are widespread in nature.

Short human eccDNAs are predictable from sequences

Background: Ubiquitous presence of short extrachromosomal circular DNAs (eccDNAs) in eukaryotic cells has perplexed generations of …

pubmedKB: an interactive web server for exploring biomedical entity relations in the biomedical literature

With the proliferation of genomic sequence data for biomedical research, the exploration of human genetic information by domain experts …

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