Welcoming new interns and friends to our lab—let’s explore, learn, and grow together!

One lab group photo over delicious duck dinner — good luck, Jeff! Wishing you all the best on your new path. We were also delighted to welcome back 詠晴

A delightful lunch and a warm welcome to Serina! Group photo in front of Fulong Train Station — we’re about to start our bike ride! Another shot at the entrance of the Old Caoling Tunnel — little did we know we would end up completing the entire cycling route!

Enhanced phenotypic diversity increases a population’s likelihood of surviving catastrophic conditions. Hsp90, an essential molecular chaperone and a central network hub in eukaryotes, has been observed to suppress or enhance the effects of genetic variation on phenotypic diversity in response to environmental cues. Because many Hsp90-interacting genes are involved in signaling transduction pathways and transcriptional regulation, we tested how common Hsp90-dependent differential gene expression is in natural populations. Many genes exhibited Hsp90-dependent strain-specific differential expression in five diverse yeast strains. We further identified transcription factors (TFs) potentially contributing to variable expression. We found that on Hsp90 inhibition or environmental stress, activities or abundances of Hsp90-dependent TFs varied among strains, resulting in differential strain-specific expression of their target genes, which consequently led to phenotypic diversity. We provide evidence that individual strains can readily display specific Hsp90-dependent gene expression, suggesting that the evolutionary impacts of Hsp90 are widespread in nature.

Background: Ubiquitous presence of short extrachromosomal circular DNAs (eccDNAs) in eukaryotic cells has perplexed generations of …

With the proliferation of genomic sequence data for biomedical research, the exploration of human genetic information by domain experts …